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12-Month peak alpha frequency is a correlate but not a longitudinal predictor of non-verbal cognitive abilities in infants at low and high risk for autism spectrum disorder

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the BASIS TEAM

Original languageEnglish
Article number100938
JournalDevelopmental Cognitive Neuroscience
Volume48
DOIs
PublishedApr 2021

Bibliographical note

Funding Information: BASIS data were collected with support from the UK Medical Research Council and Autistica . The authors acknowledge the following sources of funding: NIMH ( U19 MH108206 ), NIH ( P50 HD055782 ), Autism Science Foundation, Autism Speaks (SW); Azrieli Centre for Autism Research (MA); Quebec Autism Research Trainee award provided by the Transforming Autism Care Consortium (TACC) (SH, SvN); NIHR ( NF-SI-0617-10120 ) and Biomedical Research Centre at South London , and Maudsley NHS Foundation Trust and King’s College London (AP); Sir Henry Wellcome Postdoctoral Fellowship ( 213608/Z/18/Z ) (VCL). Publisher Copyright: © 2021 Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

King's Authors

Abstract

Although studies of PAF in individuals with autism spectrum disorder (ASD) report group differences and associations with non-verbal cognitive ability, it is not known how PAF relates to familial risk for ASD, and whether similar associations with cognition in are present in infancy. Using a large multi-site prospective longitudinal dataset of infants with low and high familial risk for ASD, metrics of PAF at 12 months were extracted and growth curves estimated for cognitive development between 12–36 months. Analyses tested whether PAF 1) differs between low and high risk infants, 2) is associated with concurrent non-verbal/verbal cognitive ability and 3) predicts developmental change in non-verbal/verbal ability. Moderation of associations between PAF and cognitive ability by familial risk status was also tested. No differences in 12-month PAF were found between low and high risk infants. PAF was associated with concurrent non-verbal cognitive ability, but did not predict change in non-verbal cognitive over development. No associations were found between PAF and verbal ability, along with no evidence of moderation. PAF is not related to familial risk for ASD, and is a neural marker of concurrent non-verbal cognitive ability, but not verbal ability, in young infants at low and high risk for ASD

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