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Unconventional Biocatalytic Approaches to the Synthesis of Chiral Sulfoxides

Research output: Contribution to journalReview articlepeer-review

Original languageEnglish
Pages (from-to)298-307
Number of pages10
Issue number2
Early online date31 Jul 2020
Accepted/In press1 Jan 2020
E-pub ahead of print31 Jul 2020
Published15 Jan 2021

Bibliographical note

Funding Information: We gratefully acknowledge BBSRC LIDo (BB/M009513/1) for PhD Studentship to S.A. Publisher Copyright: © 2020 The Authors. Published by Wiley-VCH GmbH

King's Authors


Sulfoxides are a class of organic compounds that find wide application in medicinal and organic chemistry. Several biocatalytic approaches have been developed to synthesise enantioenriched sulfoxides, mainly by exploiting oxidative enzymes. Recently, the use of reductive enzymes such as Msr and Dms has emerged as a new, alternative method to obtain enantiopure sulfoxides from racemic mixtures. In parallel, novel oxidative approaches, employing nonclassical solvents such as ionic liquids (ILs) and deep eutectic solvents (DESs), have been developed as greener and more sustainable biocatalytic synthetic pathways. This minireview aims highlights the recent advances made in the biocatalytic synthesis of enantioenriched sulfoxides by employing such unconventional approaches.

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