Dr Valeria Mondelli
Clinical Professor of Psychoneuroimmunology
Contact details:
Telephone: 80352
E-mail: valeria.mondelli@kcl.ac.uk
ORCID: 0000-0001-8690-6839
Scopus Author ID: 15073211100
Department
Research Group
Research interests
Dr Mondelli's research interest focuses on the interplay between physical and mental health and on the role of biological systems involved in the stress response in the pathogenesis of psychiatric disorders. Among her most important research achievements: first, she described abnormal biological response to stress at onset of psychosis; second, she identified the biological response to stress (including inflammation and cortisol secretion) as one of the factors contributing to the brain abnormalities found at psychosis onset; and third, she showed that increased inflammatory markers and cortisol at the onset of psychosis predict a poor treatment response at 3-month follow-up. More recently she has started leading two main projects to investigate the involvement of inflammation in the pathogenesis and treatment response in depression, including a clinical trial testing the effects of anti-inflammatory treatment in treatment resistant depression. She has also leading a new project looking at the link between obesity and depression in patients undergoing bariatric surgery. She has recently been awarded £1.2M by MQ to lead a new global mental health consortium aiming to identify predictors of depression early in adolescence (IDEA project). Dr Mondelli is also the NIHR SLaM BRC Research Champion in mental and physical interface.
The interaction between kynurenine pathway, suicidal ideation and augmentation therapy with minocycline in patients with treatment-resistant depression
Nettis, M. A., Lombardo, G., Hastings, C., Zajkowska, Z., Mariani, N., Nikkheslat, N., Sforzini, L., Worrell, C., Begum, A., Brown, M., Cleare, A. J., Young, A. H., Pariante, C. M. & Mondelli, V., 15 May 2023, (E-pub ahead of print) In: Journal of psychopharmacology (Oxford, England). p. 2698811231173588Research output: Contribution to journal › Article › peer-review
An MRI-based morphometric and structural covariance network study of Brazilian adolescents stratified by depression risk
Rohrsetzer, F., Balardin, J. B., Picon, F. A., Sato, J. R., Battel, L., Viduani, A., Manfro, P. H., Yoon, L., Kohrt, B. A., Fisher, H., Mondelli, V., Swartz, J. & Kieling, C., 13 May 2023, (E-pub ahead of print) In: Brazilian Journal of Psychiatry.Research output: Contribution to journal › Article › peer-review
The Association between Peripheral Inflammation, Brain Glutamate and Antipsychotic Response in Schizophrenia: data from the STRATA collaboration
Fenn-Moltu, S., Deakin, B., Drake, R., Howes, O., Lawrie, S., Lewis, S. W., Nikkheslat, N., Walters, J., Maccabe, J., Mondelli, V. & Egerton, A., 9 May 2023, (Accepted/In press) In: Brain Behavior and Immunity.Research output: Contribution to journal › Article › peer-review
Gone Too Soon: priorities for action to prevent premature mortality associated with mental illness and mental distress
O'Connor, R. C., Worthman, C. M., Abanga, M., Athanassopoulou, N., Boyce, N., Chan, L. F., Christensen, H., Das-Munshi, J., Downs, J., Koenen, K. C., Moutier, C. Y., Templeton, P., Batterham, P., Brakspear, K., Frank, R. G., Gilbody, S., Gureje, O., Henderson, D., John, A., Kabagambe, W., & 20 others, 5 May 2023, (E-pub ahead of print) In: The lancet. Psychiatry. 10, 6, p. 452-464 13 p.Research output: Contribution to journal › Review article › peer-review
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- 1071
Markers of central inflammation in major depressive disorder: a systematic review and meta-analysis of studies examining cerebrospinal fluid, positron emission tomography and post-mortem brain tissue
Research output: Contribution to journal › Article › peer-review
downloads - 769
Brain microglia in psychiatric disorders
Research output: Contribution to journal › Article › peer-review
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Further evidence of a cumulative effect of social disadvantage on risk of psychosis
Research output: Contribution to journal › Article › peer-review
downloads - 510
Impact of childhood adversities on specific symptom dimensions in first-episode psychosis
Research output: Contribution to journal › Article › peer-review
downloads - 480
Early-Life Adversity, Systemic Inflammation and Comorbid Physical and Psychiatric Illnesses of Adult Life
Research output: Contribution to journal › Article › peer-review
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